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Educational purposes only — not medical advice. Consult your gastroenterologist before changing any regimen. Full disclaimer We may earn a commission on recommended products, at no extra cost to you. Disclosure

Category 03

Emerging natural & integrative therapies

The frontier of gut-health research: peptides, plant compounds and integrative approaches with compelling mechanisms that big pharma has little incentive to study. Our community data will help map what they can do.

BPC-157

Emerging

Body Protection Compound 157 · Pentadecapeptide BPC 157 · PL 14736

A healing peptide derived from gastric juice, with remarkable research on gut-lining repair, anastomosis healing and fistula closure.

3 studies summarised
Read the evidence

N-Acetyl Glucosamine

Emerging

NAG · GlcNAc · N-acetylglucosamine

A building block of the protective mucus layer that lines your gut. A pediatric pilot study reported striking improvements in hard-to-treat IBD.

1 study summarised
Read the evidence

Berberine

Emerging

Berberine hydrochloride · Coptis chinensis · Huang lian

A golden plant alkaloid from traditional Chinese and Ayurvedic medicine that supports gut barrier integrity and a balanced microbiome.

1 study summarised
Read the evidence

Quercetin

Emerging

Quercetin dihydrate · Isoquercetin · Quercetin phytosome

A flavonoid found in onions, apples and capers that supports healthy inflammasome activity and gut barrier function.

2 studies summarised
Read the evidence

EGCG / Green Tea Extract

Emerging

Epigallocatechin-3-gallate · Polyphenon E · Green tea catechins

Green tea’s key polyphenol, which stays concentrated in the gut and showed encouraging results in an ulcerative colitis pilot.

2 studies summarised
Read the evidence

Low-Dose Naltrexone (LDN)

Early clinical

LDN · Naltrexone 4.5 mg · Opioid antagonist microdose

An off-label, low-dose use of an established medication that has shown promising results in Crohn’s trials and has a devoted patient following.

3 studies summarised
Read the evidence

Phase 2 — in development

Where traditional research stops, our community begins

Natural compounds can’t be patented, so they rarely get the multi-million-dollar trials that drugs receive. That leaves people with Crohn’s without answers to the questions that matter most: what actually helps, at what dose, and for whom? Our Community Symptom Tracker will crowdsource those answers from real people living with Crohn’s, and our upcoming wellness store will make it easy to find quality, third-party-tested products.

  • Log your symptoms, supplements and doses in a private daily tracker
  • See what’s working for people with the same disease location and medications
  • Contribute to the largest real-world dataset on natural Crohn’s support
  • Shop curated, third-party-tested protocols from our upcoming store

Be one of the first to join

Early access is opening soon. Bookmark this page and check back — we’ll announce sign-ups here first.

Early access opening soon Read our mission